Internet Censorship: An Integrative Review of Technologies Employed to Limit Access to the Internet, Monitor User Actions, and their Effects on Culture

The following conducts an integrative review of the current state of Internet Censorship in China, Iran, and Russia, highlights common circumvention technologies (CTs), and analyzes the effects Internet Censorship has on cultures. The author spends a large majority of the paper delineating China’s Internet infrastructure and prevalent Internet Censorship Technologies/Techniques (ICTs), paying particular attention to how the ICTs function at a technical level. The author further analyzes the state of Internet Censorship in both Iran and Russia from a broader perspective to give a better understanding of Internet Censorship around the globe. The author also highlights specific CTs, explaining how they function at a technical level. Findings indicate that among all three nation-states, state control of Internet Service Providers is the backbone of Internet Censorship. Specifically, within China, it is discovered that the infrastructure functions as an Intranet, thereby creating a closed system. Further, BGP Hijacking, DNS Poisoning, and TCP RST attacks are analyzed to understand their use-case within China. It is found that Iran functions much like a weaker version of China in regards to ICTs, with the state seemingly using the ICT of Bandwidth Throttling rather consistently. Russia’s approach to Internet censorship, in stark contrast to Iran and China, is found to rely mostly on the legislative system and fear to implement censorship, though their technical level of ICT implementation grows daily. TOR, VPNs, and Proxy Servers are all analyzed and found to be robust CTs. Drawing primarily from the examples given throughout the paper, the author highlights the various effects of Internet Censorship on culture – noting that at its core, Internet Censorship destroys democracy

University of Michigan's Aerospace Engineering Curriculum 2000

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76554/1/AIAA-1997-734-689.pd

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

Gold nanoparticles (GNPs) are being proposed as contrast agents to enhance X-ray imaging and radiotherapy, seeking to take advantage of the increased X-ray absorption of gold compared to soft tissue. However, there is a great discrepancy between physically predicted increases in X-ray energy deposition and experimentally observed increases in cell killing. In this work, we present the first calculations which take into account the structure of energy deposition in the nanoscale vicinity of GNPs and relate this to biological outcomes, and show for the first time good agreement with experimentally observed cell killing by the combination of X-rays and GNPs. These results are not only relevant to radiotherapy, but also have implications for applications of heavy atom nanoparticles in biological settings or where human exposure is possible because the localised energy deposition high-lighted by these results may cause complex DNA damage, leading to mutation and carcinogenesis.</p

Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Population

The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination

Convergent Processing of Both Positive and Negative Motivational Signals by the VTA Dopamine Neuronal Populations

Dopamine neurons in the ventral tegmental area (VTA) have been traditionally studied for their roles in reward-related motivation or drug addiction. Here we study how the VTA dopamine neuron population may process fearful and negative experiences as well as reward information in freely behaving mice. Using multi-tetrode recording, we find that up to 89% of the putative dopamine neurons in the VTA exhibit significant activation in response to the conditioned tone that predict food reward, while the same dopamine neuron population also respond to the fearful experiences such as free fall and shake events. The majority of these VTA putative dopamine neurons exhibit suppression and offset-rebound excitation, whereas ∼25% of the recorded putative dopamine neurons show excitation by the fearful events. Importantly, VTA putative dopamine neurons exhibit parametric encoding properties: their firing change durations are proportional to the fearful event durations. In addition, we demonstrate that the contextual information is crucial for these neurons to respectively elicit positive or negative motivational responses by the same conditioned tone. Taken together, our findings suggest that VTA dopamine neurons may employ the convergent encoding strategy for processing both positive and negative experiences, intimately integrating with cues and environmental context

Differential Carbohydrate Recognition by Campylobacter jejuni Strain 11168: Influences of Temperature and Growth Conditions

The pathogenic clinical strain NCTC11168 was the first Campylobacter jejuni strain to be sequenced and has been a widely used laboratory model for studying C. jejuni pathogenesis. However, continuous passaging of C. jejuni NCTC11168 has been shown to dramatically affect its colonisation potential. Glycan array analysis was performed on C. jejuni NCTC11168 using the frequently passaged, non-colonising, genome sequenced (11168-GS) and the infrequently passaged, original, virulent (11168-O) isolates grown or maintained under various conditions. Glycan structures recognised and bound by C. jejuni included terminal mannose, N-acetylneuraminic acid, galactose and fucose. Significantly, it was found that only when challenged with normal oxygen at room temperature did 11168-O consistently bind to sialic acid or terminal mannose structures, while 11168-GS bound these structures regardless of growth/maintenance conditions. Further, binding of un-capped galactose and fucosylated structures was significantly reduced when C. jejuni was maintained at 25°C under atmospheric oxygen conditions. These binding differences identified through glycan array analysis were confirmed by the ability of specific lectins to competitively inhibit the adherence of C. jejuni to a Caco-2 intestinal cell line. Our data suggests that the binding of mannose and/or N-acetylneuraminic acid may provide the initial interactions important for colonisation following environmental exposure

A Implementation Plan for the Rainwater Basin Joint Venture

Nebraska\u27s Rainwater Basin (RWB) wetland area is identified by the North American Waterfowl Management Plan (NAWMP) as a waterfowl habitat area of major concern in North America. The Rainwater Basin area is recognized as the focal point of a spring migration corridor used by millions of ducks and geese annually (Figure 1). This migration corridor is shaped like an hourglass, with the Rainwater Basin and Central Platte River located at the constriction